Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Glucocorticoids (GCs) are the most commonly used antiinflammatory and immunosuppressive drugs. Their outstanding therapeutic effects, however, are often accompanied by severe and sometimes irreversible side effects. For this reason, one goal of research in the GC field is the development of new drug...

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Autors principals: Schäcke, Heike, Schottelius, Arndt, Döcke, Wolf-Dietrich, Strehlke, Peter, Jaroch, Stefan, Schmees, Norbert, Rehwinkel, Hartmut, Hennekes, Hartwig, Asadullah, Khusru
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC314167/
https://ncbi.nlm.nih.gov/pubmed/14694204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0300372101
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