Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Glucocorticoids (GCs) are the most commonly used antiinflammatory and immunosuppressive drugs. Their outstanding therapeutic effects, however, are often accompanied by severe and sometimes irreversible side effects. For this reason, one goal of research in the GC field is the development of new drug...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Schäcke, Heike, Schottelius, Arndt, Döcke, Wolf-Dietrich, Strehlke, Peter, Jaroch, Stefan, Schmees, Norbert, Rehwinkel, Hartmut, Hennekes, Hartwig, Asadullah, Khusru
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 2003
נושאים:	Biological Sciences
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0300372101
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