Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Glucocorticoids (GCs) are the most commonly used antiinflammatory and immunosuppressive drugs. Their outstanding therapeutic effects, however, are often accompanied by severe and sometimes irreversible side effects. For this reason, one goal of research in the GC field is the development of new drug...

Descrición completa

Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Schäcke, Heike, Schottelius, Arndt, Döcke, Wolf-Dietrich, Strehlke, Peter, Jaroch, Stefan, Schmees, Norbert, Rehwinkel, Hartmut, Hennekes, Hartwig, Asadullah, Khusru
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0300372101
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!