DNA Cross-links Induced by trans-4-Hydroxynonenal

trans-4-Hydroxynonenal (HNE) is a peroxidation product of ω-6 polyunsaturated fatty acids. Michael addition of HNE to deoxyguanosine yields four diastereomeric 1,N(2)-dG adducts. The adduct of (6S,8R,11S) stereochemistry forms inter-strand N(2)-dG:N(2)-dG cross-links in the 5′-CpG-3′ sequence. It ha...

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Hauptverfasser: Huang, Hai, Kozekov, Ivan D., Kozekova, Albena, Wang, Hao, Lloyd, R. Stephen, Rizzo, Carmelo J., Stone, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140422/
https://ncbi.nlm.nih.gov/pubmed/20577992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20599
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