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Rearrangement of the (6S,8R,11S) and (6R,8S,11R) Exocyclic 1,N(2)-Deoxyguanosine Adducts of trans-4-Hydroxynonenal to N(2)-Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA
[Image: see text] trans-4-Hydroxynonenal (HNE) is a peroxidation product of ω-6 polyunsaturated fatty acids. The Michael addition of deoxyguanosine to HNE yields four diastereomeric exocyclic 1,N(2)-dG adducts. The corresponding acrolein- and crotonaldehyde-derived exocyclic 1,N(2)-dG adducts underg...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2008
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646763/ https://ncbi.nlm.nih.gov/pubmed/18661996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja801824b |
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