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Formation of a N(2)-dG:N(2)-dG Carbinolamine DNA Cross-link by the trans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N(2)-dG Adduct
[Image: see text] Michael addition of trans-4-hydroxynonenal (HNE) to deoxyguanosine yields diastereomeric 1,N(2)-dG adducts in DNA. When placed opposite dC in the 5′-CpG-3′ sequence, the (6S,8R,11S) diastereomer forms a N(2)-dG:N(2)-dG interstrand cross-link [Wang, H.; Kozekov, I. D.; Harris, T. M....
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical Society
2011
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3187658/ https://ncbi.nlm.nih.gov/pubmed/21916419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205145q |
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