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Stereospecific Formation of the (R)-γ-Hydroxytrimethylene Interstrand N(2)-dG:N(2)-dG Cross-Link Arising from the γ-OH-1,N(2)-Propano-2'-deoxyguanosine Adduct in the 5′-CpG-3′ DNA Sequence
Acrolein reacts with dG to form hydroxylated 1,N(2)-propanodeoxyguanosine (OH-PdG) adducts. Most abundant are the epimeric 3-(2-deoxy-β-D-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2a] purin-10(3H)-ones, commonly referred to as the γ-OH-PdG adduct. When placed complementary to de...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753404/ https://ncbi.nlm.nih.gov/pubmed/19530727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja809543j |
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