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Spectroscopic Characterization of Interstrand Carbinolamine Crosslinks Formed in the 5'-CpG-3' Sequence by the Acrolein-Derived γ-OH-1,N(2)-Propano-2'-deoxyguanosine DNA Adduct

The interstrand N(2),N(2)-dG DNA crosslinking chemistry of the acrolein-derived γ-OH-1,N(2)-propanodeoxyguanosine (γ-OH-PdG) adduct in the 5'-CpG-3' sequence was monitored within a dodecamer duplex by NMR spectroscopy, in situ, using a series of site-specific (13)C- and (15)N-edited experi...

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Main Authors: Cho, Young-Jin, Kim, Hye-Young, Huang, Hai, Slutsky, Alvira, Minko, Irina G., Wang, Hao, Nechev, Lubomir V., Kozekov, Ivan D., Kozekova, Albena, Tamura, Pamela, Jacob, Jaison, Voehler, Markus, Harris, Thomas M., Lloyd, R. Stephen, Rizzo, Carmelo J., Stone, Michael P.
格式: Artigo
語言:Inglês
出版: 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631571/
https://ncbi.nlm.nih.gov/pubmed/16351098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja053897e
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