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Spectroscopic Characterization of Interstrand Carbinolamine Crosslinks Formed in the 5'-CpG-3' Sequence by the Acrolein-Derived γ-OH-1,N(2)-Propano-2'-deoxyguanosine DNA Adduct

The interstrand N(2),N(2)-dG DNA crosslinking chemistry of the acrolein-derived γ-OH-1,N(2)-propanodeoxyguanosine (γ-OH-PdG) adduct in the 5'-CpG-3' sequence was monitored within a dodecamer duplex by NMR spectroscopy, in situ, using a series of site-specific (13)C- and (15)N-edited experi...

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Bibliografiske detaljer
Main Authors: Cho, Young-Jin, Kim, Hye-Young, Huang, Hai, Slutsky, Alvira, Minko, Irina G., Wang, Hao, Nechev, Lubomir V., Kozekov, Ivan D., Kozekova, Albena, Tamura, Pamela, Jacob, Jaison, Voehler, Markus, Harris, Thomas M., Lloyd, R. Stephen, Rizzo, Carmelo J., Stone, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631571/
https://ncbi.nlm.nih.gov/pubmed/16351098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja053897e
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