Chemistry and Biology of DNA Containing 1,N(2)-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal

[Image: see text] The α,β-unsaturated aldehydes (enals) acrolein, crotonaldehyde, and trans-4-hydroxynonenal (4-HNE) are products of endogenous lipid peroxidation, arising as a consequence of oxidative stress. The addition of enals to dG involves Michael addition of the N(2)-amine to give N(2)-(3-ox...

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Päätekijät: Minko, Irina G., Kozekov, Ivan D., Harris, Thomas M., Rizzo, Carmelo J., Lloyd, R. Stephen, Stone, Michael P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2009
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685875/
https://ncbi.nlm.nih.gov/pubmed/19397281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx9000489
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