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Chemistry and Biology of DNA Containing 1,N(2)-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal
[Image: see text] The α,β-unsaturated aldehydes (enals) acrolein, crotonaldehyde, and trans-4-hydroxynonenal (4-HNE) are products of endogenous lipid peroxidation, arising as a consequence of oxidative stress. The addition of enals to dG involves Michael addition of the N(2)-amine to give N(2)-(3-ox...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685875/ https://ncbi.nlm.nih.gov/pubmed/19397281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx9000489 |
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