Simplified synthesis of individual stereoisomers of the 4-hydroxynonenal adducts of deoxyguanosine

We previously reported the synthesis of the 1,N(2)-deoxyguanosine adducts of 4-hydroxynonenal, an important product of lipid peroxidation, which involved the nucleophilic aromatic substitution reaction of an O(6)-protected-2-fluoroinosine with 4-amino-1,2,5-trihydroxydecanal followed by periodate ox...

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Hlavní autoři: Christov, Plamen P, Hawkins, Edward K., Kett, Nathan R., Rizzo, Carmelo J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735235/
https://ncbi.nlm.nih.gov/pubmed/23935223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.06.004
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