Conformational Interconversion of the trans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N(2)-Deoxyguanosine Adduct When Mismatched with Deoxyadenosine in DNA

The (6S,8R,11S) 1,N(2)-HNE-dG adduct of trans-4-hydroxynonenal (HNE) was incorporated into the duplex 5′-d(GCTAGCXAGTCC)-3′•5′-d(GGACTAGCTAGC)-3′ [X=(6S,8R,11S) HNE-dG], in which the lesion was mismatched opposite dA. The (6S,8R,11S) adduct maintained the ring-closed 1,N(2)-HNE-dG structure. This wa...

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Hlavní autoři: Huang, Hai, Wang, Hao, Lloyd, R. Stephen, Rizzo, Carmelo J., Stone, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645987/
https://ncbi.nlm.nih.gov/pubmed/19053179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800320m
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