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The Stereochemistry of trans-4-Hydroxynonenal-Derived Exocyclic 1,N(2)-2′-Deoxyguanosine Adducts Modulates Formation of Interstrand Cross-Links in the 5′-CpG-3′ Sequence
[Image: see text] The trans-4-hydroxynonenal (HNE)-derived exocyclic 1,N(2)-dG adduct with (6S,8R,11S) stereochemistry forms interstrand N(2)-dG−N(2)-dG cross-links in the 5′-CpG-3′ DNA sequence context, but the corresponding adduct possessing (6R,8S,11R) stereochemistry does not. Both exist primari...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical Society
2008
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646759/ https://ncbi.nlm.nih.gov/pubmed/18847226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8011143 |
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