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Conformational Interconversion of the trans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N(2)-Deoxyguanosine Adduct When Mismatched with Deoxyadenosine in DNA
The (6S,8R,11S) 1,N(2)-HNE-dG adduct of trans-4-hydroxynonenal (HNE) was incorporated into the duplex 5′-d(GCTAGCXAGTCC)-3′•5′-d(GGACTAGCTAGC)-3′ [X=(6S,8R,11S) HNE-dG], in which the lesion was mismatched opposite dA. The (6S,8R,11S) adduct maintained the ring-closed 1,N(2)-HNE-dG structure. This wa...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645987/ https://ncbi.nlm.nih.gov/pubmed/19053179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800320m |
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