γ-Hydroxy-1,N(2)-propano-2′-deoxyguanosine DNA Adduct Conjugates the N-Terminal Amine of the KWKK Peptide via a Carbinolamine Linkage

[Image: see text] The γ-hydroxy-1,N(2)-propano-2′-deoxyguanosine adduct (γ-OH-PdG) was introduced into 5′-d(GCTAGCXAGTCC)-3′·5′-d(GGACTCGCTAGC)-3′ (X = γ-OH-PdG). In the presence of excess peptide KWKK, (13)C isotope-edited NMR revealed the formation of two spectroscopically distinct DNA–KWKK conjug...

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Detalhes bibliográficos
Main Authors: Huang, Hai, Wang, Hao, Voehler, Markus W., Kozekova, Albena, Rizzo, Carmelo J., McCullough, Amanda K., Lloyd, R. Stephen, Stone, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138414/
https://ncbi.nlm.nih.gov/pubmed/21561113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200113n
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