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DNA Cross-links Induced by trans-4-Hydroxynonenal
trans-4-Hydroxynonenal (HNE) is a peroxidation product of ω-6 polyunsaturated fatty acids. Michael addition of HNE to deoxyguanosine yields four diastereomeric 1,N(2)-dG adducts. The adduct of (6S,8R,11S) stereochemistry forms inter-strand N(2)-dG:N(2)-dG cross-links in the 5′-CpG-3′ sequence. It ha...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140422/ https://ncbi.nlm.nih.gov/pubmed/20577992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20599 |
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