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Interstrand DNA Cross-links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources

Significant levels of the 1,N(2)-γ-hydroxypropano-dG adducts of the α,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxy-2E-nonenal (HNE) have been identified in human DNA, arising from both exogenous and endogenous exposure. They yield interstrand DNA cross-links between guanines in th...

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Dettagli Bibliografici
Autori principali: Stone, Michael P., Cho, Young-Jin, Huang, Hai, Kim, Hye-Young, Kozekov, Ivan D., Kozekova, Albena, Wang, Hao, Minko, Irina G., Lloyd, R. Stephen, Harris, Thomas M., Rizzo, Carmelo J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785109/
https://ncbi.nlm.nih.gov/pubmed/18500830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ar700246x
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