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Structure of the 1,N(2)-Etheno-2′-deoxyguanosine Adduct in Duplex DNA at pH 8.6
The structure of the 1,N(2)-εdG adduct, arising from the reaction of vinyl chloride with dG, was determined in the oligonucleotide duplex 5′-d(CGCATXGAATCC)-3′•5′-d(GGATTCCATGCG)-3′ (X=1,N(2)-εdG) at pH 8.6 using high resolution NMR spectroscopy. The exocyclic lesion prevented Watson-Crick base-pair...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2546360/ https://ncbi.nlm.nih.gov/pubmed/17941687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7001788 |
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