Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-Gated Sodium Channels and in the Treatment of Neuropathic Pain

[Image: see text] We recently reported that merging key structural pharmacophores of the anticonvulsant drugs lacosamide (a functionalized amino acid) with safinamide (an α-aminoamide) resulted in novel compounds with anticonvulsant activities superior to that of either drug alone. Here, we examined...

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Hlavní autoři: Wang, Yuying, Wilson, Sarah M., Brittain, Joel M., Ripsch, Matthew S., Salomé, Christophe, Park, Ki Duk, White, Fletcher A., Khanna, Rajesh, Kohn, Harold
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134314/
https://ncbi.nlm.nih.gov/pubmed/21765969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200024z
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