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Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-Gated Sodium Channels and in the Treatment of Neuropathic Pain
[Image: see text] We recently reported that merging key structural pharmacophores of the anticonvulsant drugs lacosamide (a functionalized amino acid) with safinamide (an α-aminoamide) resulted in novel compounds with anticonvulsant activities superior to that of either drug alone. Here, we examined...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical Society
2011
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134314/ https://ncbi.nlm.nih.gov/pubmed/21765969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200024z |
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