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Prion protein biosynthesis and its emerging role in neurodegeneration

Various fatal neurodegenerative disorders are caused by altered metabolism of the prion protein (PrP). These diseases are typically transmissible by an unusual ‘protein-only’ mechanism in which a misfolded isomer, PrP(Sc), confers its aberrant conformation onto normal cellular PrP. An impressive ran...

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Bibliografske podrobnosti
Main Authors: Chakrabarti, Oishee, Ashok, Aarthi, Hegde, Ramanujan S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132587/
https://ncbi.nlm.nih.gov/pubmed/19447626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2009.03.001
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