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Prion protein biosynthesis and its emerging role in neurodegeneration
Various fatal neurodegenerative disorders are caused by altered metabolism of the prion protein (PrP). These diseases are typically transmissible by an unusual ‘protein-only’ mechanism in which a misfolded isomer, PrP(Sc), confers its aberrant conformation onto normal cellular PrP. An impressive ran...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3132587/ https://ncbi.nlm.nih.gov/pubmed/19447626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2009.03.001 |
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