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Selective Processing and Metabolism of Disease-Causing Mutant Prion Proteins
Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the cellular prion protein (PrP(C)). In genetic forms of these diseases, mutations in the globular C-terminal domain are hypothesized to favor the spontaneous generation of misfolded PrP conformers (including the t...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2691595/ https://ncbi.nlm.nih.gov/pubmed/19543376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000479 |
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