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Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration
The pathways leading from aberrant Prion protein (PrP) metabolism to neurodegeneration are poorly understood. Some familial PrP mutants generate increased (Ctm)PrP, a transmembrane isoform associated with disease. In other disease situations, a potentially toxic cytosolic form (termed cyPrP) might b...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709807/ https://ncbi.nlm.nih.gov/pubmed/19524515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.042 |
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