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Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

The pathways leading from aberrant Prion protein (PrP) metabolism to neurodegeneration are poorly understood. Some familial PrP mutants generate increased (Ctm)PrP, a transmembrane isoform associated with disease. In other disease situations, a potentially toxic cytosolic form (termed cyPrP) might b...

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Autori principali: Chakrabarti, Oishee, Hegde, Ramanujan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709807/
https://ncbi.nlm.nih.gov/pubmed/19524515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.042
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