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Protection from cytosolic prion protein toxicity by modulation of protein translocation
Failure to promptly dispose of undesirable proteins is associated with numerous diseases. In the case of cellular prion protein (PrP), inhibition of the proteasome pathway can generate a highly aggregation-prone, cytotoxic form of PrP implicated in neurodegeneration. However, the predominant mechani...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC533048/ https://ncbi.nlm.nih.gov/pubmed/15526034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600462 |
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