Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to Neurodegeneration

During acute stress in the endoplasmic reticulum (ER), mammalian prion protein (PrP) is temporarily prevented from translocation into the ER and instead routed directly for cytosolic degradation. This ‘pre-emptive’ quality control (pQC) system benefits cells by minimizing PrP aggregation in the secr...

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Bibliografiska uppgifter
Huvudupphovsmän: Rane, Neena S., Kang, Sang-Wook, Chakrabarti, Oishee, Feigenbaum, Lionel, Hegde, Ramanujan S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563805/
https://ncbi.nlm.nih.gov/pubmed/18804434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.06.015
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