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Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to Neurodegeneration
During acute stress in the endoplasmic reticulum (ER), mammalian prion protein (PrP) is temporarily prevented from translocation into the ER and instead routed directly for cytosolic degradation. This ‘pre-emptive’ quality control (pQC) system benefits cells by minimizing PrP aggregation in the secr...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2563805/ https://ncbi.nlm.nih.gov/pubmed/18804434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.06.015 |
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