Trifluoperazine Regulation of Calmodulin Binding to Fas: A Computational Study

Death-inducing signaling complex (DISC) formation is a critical step in Fas-mediated signaling for apoptosis. Previous experiments have demonstrated that the calmodulin (CaM) antagonist, trifluoperazine (TFP) regulates CaM-Fas binding and affects Fas-mediated DISC formation. In this study, we invest...

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Bibliographic Details
Main Authors: Pan, Di, Yan, Qi, Chen, Yabing, McDonald, Jay M, Song, Yuhua
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132223/
https://ncbi.nlm.nih.gov/pubmed/21656570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23081
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