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Structural Insight for the Roles of Fas Death Domain Binding to FADD and Oligomerization Degree of the Fas - FADD complex in the Death Inducing Signaling Complex Formation: A Computational Study

Fas binding to Fas-associated death domain (FADD) activates FADD-caspase-8 binding to form death-inducing signaling complex (DISC) that triggers apoptosis. The Fas-Fas association exists primary as dimer in the Fas-FADD complex and the Fas-FADD tetramer complexes have the tendency to form higher ord...

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Detalhes bibliográficos
Main Authors: Yan, Qi, McDonald, Jay M, Zhou, Tong, Song, Yuhua
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556372/
https://ncbi.nlm.nih.gov/pubmed/23042204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24193
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