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Structural Insight for the Roles of Fas Death Domain Binding to FADD and Oligomerization Degree of the Fas - FADD complex in the Death Inducing Signaling Complex Formation: A Computational Study
Fas binding to Fas-associated death domain (FADD) activates FADD-caspase-8 binding to form death-inducing signaling complex (DISC) that triggers apoptosis. The Fas-Fas association exists primary as dimer in the Fas-FADD complex and the Fas-FADD tetramer complexes have the tendency to form higher ord...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3556372/ https://ncbi.nlm.nih.gov/pubmed/23042204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24193 |
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