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The Fas/FADD death domain complex structure unravels signaling by receptor clustering
The Death Inducing Signaling Complex (DISC) formed by Fas receptor, FADD and caspase-8 is a pivotal trigger of apoptosis1-3. The Fas/FADD DISC represents a receptor platform, which once assembled initiates the induction of programmed cell death. A highly oligomeric network of homotypic protein inter...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2661029/ https://ncbi.nlm.nih.gov/pubmed/19118384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07606 |
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