Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

Caspase-8 (casp8) is required for extrinsic apoptosis, and mice deficient in casp8 fail to develop and die in utero while ultimately failing to maintain the proliferation of T cells, B cells, and a host of other cell types. Paradoxically, these failures are not caused by a defect in apoptosis, but b...

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Detalhes bibliográficos
Main Authors: Lu, Jennifer V., Weist, Brian M., van Raam, Bram J., Marro, Brett S., Nguyen, Long V., Srinivas, Prathna, Bell, Bryan D., Luhrs, Keith A., Lane, Thomas E., Salvesen, Guy S., Walsh, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174674/
https://ncbi.nlm.nih.gov/pubmed/21876153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102779108
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