Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

Caspase-8 (casp8) is required for extrinsic apoptosis, and mice deficient in casp8 fail to develop and die in utero while ultimately failing to maintain the proliferation of T cells, B cells, and a host of other cell types. Paradoxically, these failures are not caused by a defect in apoptosis, but b...

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Hlavní autoři: Lu, Jennifer V., Weist, Brian M., van Raam, Bram J., Marro, Brett S., Nguyen, Long V., Srinivas, Prathna, Bell, Bryan D., Luhrs, Keith A., Lane, Thomas E., Salvesen, Guy S., Walsh, Craig M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174674/
https://ncbi.nlm.nih.gov/pubmed/21876153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102779108
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