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Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease

Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition. We generated transgenic mice (GAL-tg)...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Steiner, Robert A., Hohmann, John G., Holmes, Andrew, Wrenn, Craige C., Cadd, Gary, Juréus, Anders, Clifton, Donald K., Luo, Mulon, Gutshall, Mitchell, Ma, Shuang Y., Mufson, Elliott J., Crawley, Jacqueline N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
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Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31200/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11259657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061445598
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