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Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease

Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition. We generated transgenic mice (GAL-tg)...

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Sparad:
I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Steiner, Robert A., Hohmann, John G., Holmes, Andrew, Wrenn, Craige C., Cadd, Gary, Juréus, Anders, Clifton, Donald K., Luo, Mulon, Gutshall, Mitchell, Ma, Shuang Y., Mufson, Elliott J., Crawley, Jacqueline N.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31200/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11259657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061445598
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