Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease

A chimeric feline immunodeficiency virus (FIV) protease (PR) has been engineered that supports infectivity but confers sensitivity to the human immunodeficiency virus (HIV) PR inhibitors darunavir (DRV) and lopinavir (LPV). The 6s-98S PR has five replacements mimicking homologous residues in HIV PR...

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Detalhes bibliográficos
Main Authors: Lin, Ying-Chuan, Perryman, Alexander L., Olson, Arthur J., Torbett, Bruce E., Elder, John H., Stout, C. David
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107052/
https://ncbi.nlm.nih.gov/pubmed/21636894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911011681
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