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Selection of Drug-Resistant Feline Immunodeficiency Virus (FIV) Encoding FIV/HIV Chimeric Protease in the Presence of HIV-Specific Protease Inhibitors

An infectious chimeric feline immunodeficiency virus (FIV)/HIV strain carrying six HIV-like protease (PR) mutations (I37V/N55M/V59I/I98S/Q99V/P100N) was subjected to selection in culture against the PR inhibitor lopinavir (LPV), darunavir (DRV), or TL-3. LPV selection resulted in the sequential emer...

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Détails bibliographiques
Auteurs principaux: Lin, Ying-Chuan, Happer, Meaghan, Elder, John H.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719837/
https://ncbi.nlm.nih.gov/pubmed/23720716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01240-13
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