Structural Basis for Distinctions between Substrate and Inhibitor Specificities for Feline Immunodeficiency Virus and Human Immunodeficiency Virus Proteases

We used feline immunodeficiency virus (FIV) protease (PR) as a mutational framework to define determinants for the observed substrate and inhibitor specificity distinctions between FIV and human immunodeficiency virus (HIV) PRs. Multiple-substitution mutants were constructed by replacing the residue...

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Detalhes bibliográficos
Main Authors: Lin, Ying-Chuan, Beck, Zachary, Morris, Garrett M., Olson, Arthur J., Elder, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156162/
https://ncbi.nlm.nih.gov/pubmed/12767979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.12.6589-6600.2003
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