Structural Basis for Distinctions between Substrate and Inhibitor Specificities for Feline Immunodeficiency Virus and Human Immunodeficiency Virus Proteases

We used feline immunodeficiency virus (FIV) protease (PR) as a mutational framework to define determinants for the observed substrate and inhibitor specificity distinctions between FIV and human immunodeficiency virus (HIV) PRs. Multiple-substitution mutants were constructed by replacing the residue...

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Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Lin, Ying-Chuan, Beck, Zachary, Morris, Garrett M., Olson, Arthur J., Elder, John H.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2003
Sujets:	Vaccines and Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156162/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12767979/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.12.6589-6600.2003
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