Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease

Resistance to human immunodeficiency virus type 1 protease (HIV PR) inhibitors results primarily from the selection of multiple mutations in the protease region. Because many of these mutations are selected for the ability to decrease inhibitor binding in the active site, they also affect substrate...

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Detalhes bibliográficos
Main Authors: Dauber, Deborah S., Ziermann, Rainer, Parkin, Neil, Maly, Dustin J., Mahrus, Sami, Harris, Jennifer L., Ellman, Jon A., Petropoulos, Christos, Craik, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135855/
https://ncbi.nlm.nih.gov/pubmed/11773410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1359-1368.2002
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