Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease

Resistance to human immunodeficiency virus type 1 protease (HIV PR) inhibitors results primarily from the selection of multiple mutations in the protease region. Because many of these mutations are selected for the ability to decrease inhibitor binding in the active site, they also affect substrate...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Dauber, Deborah S., Ziermann, Rainer, Parkin, Neil, Maly, Dustin J., Mahrus, Sami, Harris, Jennifer L., Ellman, Jon A., Petropoulos, Christos, Craik, Charles S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Vaccines and Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135855/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11773410/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.3.1359-1368.2002
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