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Nelfinavir-Resistant, Amprenavir-Hypersusceptible Strains of Human Immunodeficiency Virus Type 1 Carrying an N88S Mutation in Protease Have Reduced Infectivity, Reduced Replication Capacity, and Reduced Fitness and Process the Gag Polyprotein Precursor Aberrantly

The evolution of human immunodeficiency virus type 1 (HIV-1) strains with reduced susceptibility to protease inhibitors (PIs) is a major cause of PI treatment failure. A subset of subjects failing a therapy regimen containing the PI nelfinavir developed mutations at position 88 in the protease regio...

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Udgivet i:J Virol
Principais autores: Resch, Wolfgang, Ziermann, Rainer, Parkin, Neil, Gamarnik, Andrea, Swanstrom, Ronald
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136408/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12163585/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.17.8659-8666.2002
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