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Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease

A chimeric feline immunodeficiency virus (FIV) protease (PR) has been engineered that supports infectivity but confers sensitivity to the human immunodeficiency virus (HIV) PR inhibitors darunavir (DRV) and lopinavir (LPV). The 6s-98S PR has five replacements mimicking homologous residues in HIV PR...

詳細記述

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書誌詳細
主要な著者: Lin, Ying-Chuan, Perryman, Alexander L., Olson, Arthur J., Torbett, Bruce E., Elder, John H., Stout, C. David
フォーマット: Artigo
言語:Inglês
出版事項: International Union of Crystallography 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107052/
https://ncbi.nlm.nih.gov/pubmed/21636894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911011681
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