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Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease

A chimeric feline immunodeficiency virus (FIV) protease (PR) has been engineered that supports infectivity but confers sensitivity to the human immunodeficiency virus (HIV) PR inhibitors darunavir (DRV) and lopinavir (LPV). The 6s-98S PR has five replacements mimicking homologous residues in HIV PR...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Lin, Ying-Chuan, Perryman, Alexander L., Olson, Arthur J., Torbett, Bruce E., Elder, John H., Stout, C. David
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: International Union of Crystallography 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107052/
https://ncbi.nlm.nih.gov/pubmed/21636894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911011681
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