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Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease
A chimeric feline immunodeficiency virus (FIV) protease (PR) has been engineered that supports infectivity but confers sensitivity to the human immunodeficiency virus (HIV) PR inhibitors darunavir (DRV) and lopinavir (LPV). The 6s-98S PR has five replacements mimicking homologous residues in HIV PR...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
International Union of Crystallography
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107052/ https://ncbi.nlm.nih.gov/pubmed/21636894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911011681 |
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