Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibi...

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Detalhes bibliográficos
Main Authors: Heaslet, Holly, Lin, Ying-Chuan, Tam, Karen, Torbett, Bruce E, Elder, John H, Stout, C David
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1781954/
https://ncbi.nlm.nih.gov/pubmed/17212810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-1
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