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Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Heaslet, Holly, Lin, Ying-Chuan, Tam, Karen, Torbett, Bruce E, Elder, John H, Stout, C David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1781954/
https://ncbi.nlm.nih.gov/pubmed/17212810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-1
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