Mutational analysis of the propensity for amyloid formation by a globular protein

Acylphosphatase can be converted in vitro, by addition of trifluoroethanol (TFE), into amyloid fibrils of the type observed in a range of human diseases. The propensity to form fibrils has been investigated for a series of mutants of acylphosphatase by monitoring the range of TFE concentrations that...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Chiti, Fabrizio, Taddei, Niccolò, Bucciantini, Monica, White, Paul, Ramponi, Giampietro, Dobson, Christopher M.
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2000
Matèries:	Articles
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310213/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10747012/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.7.1441
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