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Mutational analysis of the propensity for amyloid formation by a globular protein

Acylphosphatase can be converted in vitro, by addition of trifluoroethanol (TFE), into amyloid fibrils of the type observed in a range of human diseases. The propensity to form fibrils has been investigated for a series of mutants of acylphosphatase by monitoring the range of TFE concentrations that...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Chiti, Fabrizio, Taddei, Niccolò, Bucciantini, Monica, White, Paul, Ramponi, Giampietro, Dobson, Christopher M.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2000
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC310213/
https://ncbi.nlm.nih.gov/pubmed/10747012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.7.1441
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