Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

Protein aggregation and the formation of highly insoluble amyloid structures is associated with a range of debilitating human conditions, which include Alzheimer's disease, Parkinson's disease, and the Creutzfeldt–Jakob disease. Muscle acylphosphatase (AcP) has already provided significant insights...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chiti, Fabrizio, Calamai, Martino, Taddei, Niccolò, Stefani, Massimo, Ramponi, Giampietro, Dobson, Christopher M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Colloquium Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139903/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12374855/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212527999
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