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Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

Protein aggregation and the formation of highly insoluble amyloid structures is associated with a range of debilitating human conditions, which include Alzheimer's disease, Parkinson's disease, and the Creutzfeldt–Jakob disease. Muscle acylphosphatase (AcP) has already provided significant...

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Hlavní autoři: Chiti, Fabrizio, Calamai, Martino, Taddei, Niccolò, Stefani, Massimo, Ramponi, Giampietro, Dobson, Christopher M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC139903/
https://ncbi.nlm.nih.gov/pubmed/12374855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212527999
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