A de novo protein binding pair by computational design and directed evolution

The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable new approaches to biological and medical challenges. Here we describe a novel motif-based method to computationally design protein-prot...

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Autores principales: Karanicolas, John, Corn, Jacob E., Chen, Irwin, Joachimiak, Lukasz A., Dym, Orly, Peck, Sun H., Albeck, Shira, Unger, Tamar, Hu, Wenxin, Liu, Gaohua, Delbecq, Scott, Montelione, Gaetano, Spiegel, Clint, Liu, David R., Baker, David
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102007/
https://ncbi.nlm.nih.gov/pubmed/21458342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.010
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