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Ultrahigh specificity in a network of computationally designed protein-interaction pairs

Protein networks in all organisms comprise homologous interacting pairs. In these networks, some proteins are specific, interacting with one or a few binding partners, whereas others are multispecific and bind a range of targets. We describe an algorithm that starts from an interacting pair and desi...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Netzer, Ravit, Listov, Dina, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Knop, Orli, Kleanthous, Colin, Fleishman, Sarel J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290019/
https://ncbi.nlm.nih.gov/pubmed/30538236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07722-9
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