Načítá se...

Highly active enzymes by automated combinatorial backbone assembly and sequence design

Automated design of enzymes with wild-type-like catalytic properties has been a long-standing but elusive goal. Here, we present a general, automated method for enzyme design through combinatorial backbone assembly. Starting from a set of homologous yet structurally diverse enzyme structures, the me...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Lapidoth, Gideon, Khersonsky, Olga, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Rogotner, Shelly, Fleishman, Sarel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050298/
https://ncbi.nlm.nih.gov/pubmed/30018322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05205-5
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!