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Incorporating an allosteric regulatory site in an antibody through backbone design

Allosteric regulation underlies living cells' ability to sense changes in nutrient and signaling‐molecule concentrations, but the ability to computationally design allosteric regulation into non‐allosteric proteins has been elusive. Allosteric‐site design is complicated by the requirement to en...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Khersonsky, Olga, Fleishman, Sarel J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368060/
https://ncbi.nlm.nih.gov/pubmed/28142198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3126
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